RUSSELL RYAN LAB
Targeting cancer gene regulation in lymphoid malignancies
RESEARCH
Flipping the switch on driver oncogenes
B CELL LYMPHOMAS AND LEUKEMIAS
Cancers that develop from B cells affect patients of all ages, and are diverse in their biology and clinical behavior. By uncovering the unique dependencies of specific leukemia and lymphoma subtypes, we seek to define more effectively tailored treatment strategies for individual cancer patients.
ONCOGENE ENHANCERS
We use a combination of genome-wide chromatin profiling technologies and high-throughput Cas9-based functional screening approaches to dissect the mechanisms that sustain expression of genes critical for the growth and survival of lymphoid cancers
NOTCH SIGNALING
Mutations in Notch receptor genes are recurrent in several types of lymphoid cancer, but the mechanisms by which Notch drives mature B cell lymphomas remains poorly understood. We identified genome-wide direct targets of Notch in mature B cell cancers, and are working to understand the process by which the Notch regulome sustains lymphoma.
Want to learn more about our research projects?
NEWS
What we're up to
CONGRATULATIONS ASHWIN!
July 2023
Ashwin Iyer successfully defended his PhD thesis on enhancer dependencies in MYC-intact and MYC-rearranged Diffuse Large B-cell Lymphoma.
WE'RE MOVING!
September 2018
The Ryan lab is moving from the LSI to our new home on the 4th floor of the Rogel Cancer Center building. We're excited to be located in the heart of the U-M Medical Campus, and to explore collaborations with our new neighbors in Pathology and Hematology-Oncology.
LAB MEMBERS
RUSSELL RYAN, MD
Principal Investigator
ALEC MONOVICH
Graduate Student - Molecular & Cellular Pathology
ASHWIN IYER
Graduate Student - Molecular & Cellular Pathology
AISHWARYA GURUMURTHY, PHD
Postdoctoral Fellow
JOSHUA GOLDMAN, MD
Pediatric Hematologist
ATHALEE AGUILAR
Technician / Lab Manager
ARVIND EMMANUEL
Undergraduate Student
SELECTED PUBLICATIONS
SELECTIVE ENHANCER DEPENDENCIES IN MYC-INTACT AND MYC-REARRANGED GERMINAL CENTER B-CELL DIFFUSE LARGE B-CELL LYMPHOMA
We used custom high-throughput CRISPR-interference screens to identify essential enhancers in the MYC locus and MYC rearrangement partner loci, identifying novel regulators of MYC expression in diffuse large B-cell lymphoma
ETV6 DEFICIENCY UNLOCKS ERG-DEPENDENT MICROSATELLITE ENHANCERS TO DRIVE ABERRANT GENE ACTIVATION IN B-LYMPHOBLASTIC LEUKEMIA
We identified conversion of GGAA tandem repeat elements into active enhancers as a key mechanism underlying the leukemia-specific gene expression program of a common form of childhood leukemia.
A B CELL REGULOME LINKS NOTCH TO DOWNSTREAM ONCOGENIC PATHWAYS IN SMALL B CELL LYMPHOMAS
We identified Notch as a direct activator of the 5' MYC enhancers in mantle cell lymphoma, and identified a genome-wide set of direct functional Notch target genes relevant to the biology of mantle cell lymphoma and chronic lymphocytic leukemia. Collaborative work with the laboratories of Dr. Bradley Bernstein, Warren Pear, and Jon Aster.
DETECTION OF ENHANCER-ASSOCIATED REARRANGEMENTS REVEALS MECHANISMS OF ONCOGENE DYSREGULATION IN B-CELL LYMPHOMA
We used a novel approach to simultaneously identify enhancer activity and genomic rearrangements across diverse lymphoma subtypes. In lymphomas lacking rearrangements of the oncogenes MYC and BCL6, lymphoma subtype- and tissue-specific distal enhancers were associated with oncogene activation. Work conducted in the laboratory of Dr. Bradley Bernstein.
July 12, 2023
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FORMER LAB MEMBERS
JUHI GUPTA
Now: Medical School, University of Chicago
CODY HALL
Now: Medical School, Central Michigan University
TRAVIS SAARI
Now: Bioinformatics Core, University of Michigan
CONTACT US
1500 E Medical Center Dr.
Rogel Cancer Center, Room 4130
Ann Arbor, MI 48109-5936
rjhryan [at] med.umich.edu
P: 734-936-2499
F: 734-763-2162