RUSSELL RYAN LAB
Targeting cancer gene regulation in lymphoid malignancies
Flipping the switch on driver oncogenes
B CELL LYMPHOMAS AND LEUKEMIAS
Cancers that develop from B cells affect patients of all ages, and are diverse in their biology and clinical behavior. By uncovering the unique dependencies of specific leukemia and lymphoma subtypes, we seek to define more effectively tailored treatment strategies for individual cancer patients.
We use a combination of genome-wide chromatin profiling technologies and high-throughput Cas9-based functional screening approaches to dissect the mechanisms that sustain expression of genes critical for the growth and survival of lymphoid cancers
Mutations in Notch receptor genes are recurrent in several types of lymphoid cancer, but the mechanisms by which Notch drives mature B cell lymphomas remains poorly understood. We identified genome-wide direct targets of Notch in mature B cell cancers, and are working to understand the process by which the Notch regulome sustains lymphoma.
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What we're up to
The Ryan lab is moving from the LSI to our new home on the 4th floor of the Rogel Cancer Center building. We're excited to be located in the heart of the U-M Medical Campus, and to explore collaborations with our new neighbors in Pathology and Hematology-Oncology.
RUSSELL RYAN, MD
Graduate Student - Molecular & Cellular Pathology
Graduate student - Bioinformatics
Technician / Lab Manager
JOHN RUNGE, PHD
A B CELL REGULOME LINKS NOTCH TO DOWNSTREAM ONCOGENIC PATHWAYS IN SMALL B CELL LYMPHOMAS
DETECTION OF ENHANCER-ASSOCIATED REARRANGEMENTS REVEALS MECHANISMS OF ONCOGENE DYSREGULATION IN B-CELL LYMPHOMA
FORMER LAB MEMBERS
Now: Medical School, University of Chicago
Now: Medical School, Central Michigan University
Now: Bioinformatics Core, University of Michigan