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RUSSELL RYAN LAB

Targeting cancer gene regulation in lymphoid malignancies

 

RESEARCH

Flipping the switch on driver oncogenes

 

B CELL LYMPHOMAS AND LEUKEMIAS

Cancers that develop from B cells affect patients of all ages, and are diverse in their biology and clinical behavior. By uncovering the unique dependencies of specific leukemia and lymphoma subtypes, we seek to define more effectively tailored treatment strategies for individual cancer patients.

ONCOGENE ENHANCERS

We use a combination of genome-wide chromatin profiling technologies and high-throughput Cas9-based functional screening approaches to dissect the mechanisms that sustain expression of genes critical for the growth and survival of lymphoid cancers

NOTCH SIGNALING

Mutations in Notch receptor genes are recurrent in several types of lymphoid cancer, but the mechanisms by which Notch drives mature B cell lymphomas remains poorly understood. We identified genome-wide direct targets of Notch in mature B cell cancers, and are working to understand the process by which the Notch regulome sustains lymphoma.

Want to learn more about our research projects?

NEWS

What we're up to

WE'RE MOVING!

September 2018

The Ryan lab is moving from the LSI to our new home on the 4th floor of the Rogel Cancer Center building. We're excited to be located in the heart of the U-M Medical Campus, and to explore collaborations with our new neighbors in Pathology and Hematology-Oncology.

 

LAB MEMBERS

 

RUSSELL RYAN, MD

Principal Investigator

ROHAN KODGULE

Postdoctoral Fellow

ASHWIN IYER

Graduate Student - Molecular & Cellular Pathology

VISWES RAVIKUMAR

Graduate student - Bioinformatics

NIHARIKA RAJESH

Technician / Lab Manager

JOHN RUNGE, PHD

Medical Student

MATT WEISS

Undergraduate Student

ABDULLAH RAMZAN

Undergraduate Student

SELECTED PUBLICATIONS

 

A B CELL REGULOME LINKS NOTCH TO DOWNSTREAM ONCOGENIC PATHWAYS IN SMALL B CELL LYMPHOMAS

DETECTION OF ENHANCER-ASSOCIATED REARRANGEMENTS REVEALS MECHANISMS OF ONCOGENE DYSREGULATION IN B-CELL LYMPHOMA

FORMER LAB MEMBERS

 

JUHI GUPTA

Now: Medical School, University of Chicago

CODY HALL

Now: Medical School, Central Michigan University

TRAVIS SAARI

Now: Bioinformatics Core, University of Michigan

CONTACT US

1500 E Medical Center Dr.   
Rogel Cancer Center, Room 4130
Ann Arbor, MI 48109-5936

rjhryan [at] med.umich.edu

P: 734-936-2499

F: 734-763-2162